Synthesis and antibacterial screening of hydrazones, Schiff and Mannich bases of isatin derivatives.
Eur J Med Chem
; 36(7-8): 615-25, 2001.
Article
en En
| MEDLINE
| ID: mdl-11600231
ABSTRACT
Schiff bases and hydrazones of substituted isatins (1-28) were prepared by reacting isatin and aromatic primary amines/hydrazines. A new series of the corresponding N-Mannich base (29-35) was synthesised by reacting them with formaldehyde and diphenyl amine. The chemical structures were confirmed by means of 1H-NMR, IR spectral data and elemental analysis. The compounds were screened for antibacterial activity against seven Gram (+) and seven Gram (-) standard and pathological bacterial strains by the paper disc diffusion technique. The minimum inhibitory concentrations of the active compounds were determined. 1-Diphenyl amino-methyl-3-(4-bromo phenylimino)-1,3-dihydro-indol-3-one (30) and 3-(4-bromo phenylimino)-5-nitro-1,3-dihydro-indol-3-one (13) were found to be the most active compounds of the series. Mannich bases exhibited higher activity than the corresponding Schiff bases.
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Bases de datos:
MEDLINE
Asunto principal:
Bases de Schiff
/
Hidrazonas
/
Indoles
/
Isatina
/
Bases de Mannich
/
Antibacterianos
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
Eur J Med Chem
Año:
2001
Tipo del documento:
Article
País de afiliación:
India