Design, synthesis and preliminary evaluation of novel 3'-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors.
Bioorg Med Chem Lett
; 11(24): 3179-82, 2001 Dec 17.
Article
en En
| MEDLINE
| ID: mdl-11720869
ABSTRACT
Two novel 3'-substituted carboxycylopropylglycines, (2S,1'S,2'S,3'R)-2-(3'-xanthenylmethyl-2'-carboxycyclopropyl)glycine (8a) and (2S,1'S,2'S,3'R)-2-(3'-xanthenylethyl-2'-carboxycyclopropyl)glycine (8b), were synthesized and evaluated as mGluR ligands. Compound 8b showed to be a potent group II antagonist with submicromolar activity.
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Bases de datos:
MEDLINE
Asunto principal:
Receptores de Glutamato Metabotrópico
/
Antagonistas de Aminoácidos Excitadores
/
Glicina
Idioma:
En
Revista:
Bioorg Med Chem Lett
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia