New readily accessible peroxides with high anti-malarial potency.
Bioorg Med Chem Lett
; 12(1): 69-72, 2002 Jan 07.
Article
en En
| MEDLINE
| ID: mdl-11738575
ABSTRACT
In an explorative study for new anti-malarial substances using the methyl esters (1 and 2) of peroxyplakoric acids A(3) and B(3) as scaffolds, 6-carbomethoxymethyl-3-methoxy-3-pentyl-1,2-dioxane, which has been readily synthesized from 6-keto-alpha,beta-unsaturated ester, was found to exhibit potent anti-malarial activity with high selective toxicity.
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Bases de datos:
MEDLINE
Asunto principal:
Peróxidos
/
Antimaláricos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Año:
2002
Tipo del documento:
Article
País de afiliación:
Japón