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A combinatorial library of indinavir analogues and its in vitro and in vivo studies.
Cheng, Yuan; Rano, Thomas A; Huening, Tracy T; Zhang, Fengqi; Lu, Zhijian; Schleif, William A; Gabryelski, Lori; Olsen, David B; Stahlhut, Mark; Kuo, Lawrence C; Lin, Jiunn H; Xu, Xin; Jin, Lixia; Olah, Timothy V; McLoughlin, Debra A; King, Rick C; Chapman, Kevin T; Tata, James R.
Afiliación
  • Cheng Y; Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. yuan_cheng@merck.com
Bioorg Med Chem Lett ; 12(4): 529-32, 2002 Feb 25.
Article en En | MEDLINE | ID: mdl-11844665
A combinatorial library of 300HIV protease inhibitors has been synthesized. The library was screened against recombinant wild-type and mutant HIV-1 protease enzymes. The pharmacokinetics of the library was evaluated by dosing in dogs. Compounds that are notably more potent than indinavir and have favorable pharmacokinetic properties were identified.
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Bases de datos: MEDLINE Asunto principal: Inhibidores de la Proteasa del VIH / Indinavir Tipo de estudio: Prognostic_studies Idioma: En Revista: Bioorg Med Chem Lett Año: 2002 Tipo del documento: Article País de afiliación: Estados Unidos
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Bases de datos: MEDLINE Asunto principal: Inhibidores de la Proteasa del VIH / Indinavir Tipo de estudio: Prognostic_studies Idioma: En Revista: Bioorg Med Chem Lett Año: 2002 Tipo del documento: Article País de afiliación: Estados Unidos