L-Methionine-gamma-lyase, as a target to inhibit malodorous bacterial growth by trifluoromethionine.
Biochem Biophys Res Commun
; 292(4): 964-8, 2002 Apr 12.
Article
en En
| MEDLINE
| ID: mdl-11944909
Methyl mercaptan is a major component responsible for oral malodor. This compound arises from the bacterial metabolism of methionine. Here we show that the growth of Porphyromonas gingivalis, a periodontal microorganism that produces large amounts of methyl mercaptan, was strongly inhibited by l-trifluoromethionine (TFM), a fluorinated derivative of methionine. In contrast, TFM had no effect on the growth of bacteria which do not produce methyl mercaptan. In addition, the survival rate of P. gingivalis-infected mice was remarkably increased by the co-injection of TFM. These results suggest that TFM is a promising antibacterial agent specific to the malodorous oral bacteria.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Liasas de Carbono-Azufre
/
Infecciones por Bacteroidaceae
/
Porphyromonas gingivalis
/
Metionina
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2002
Tipo del documento:
Article
País de afiliación:
Japón