Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity.
Peptides
; 24(6): 919-23, 2003 Jun.
Article
en En
| MEDLINE
| ID: mdl-12948845
ABSTRACT
The paraventricular hypothalamic nucleus (PVN) appears to integrate orexigenic properties of a novel peptide, ghrelin. Thus, we examined central mechanisms underlying feeding generated by intra-PVN ghrelin. We established that 0.03 nmol of PVN-injected ghrelin was the lowest dose increasing food consumption and it induced c-Fos immunoreactivity (a marker of neuronal activation) in the PVN itself, as well as in other feeding-related brain areas, including the hypothalamic arcuate and dorsomedial nuclei, central nucleus of the amygdala, and nucleus of the solitary tract. We conclude that the PVN, as part of larger central circuitry, mediates orexigenic properties of ghrelin.
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Bases de datos:
MEDLINE
Medicinas Complementárias:
Homeopatia
Asunto principal:
Proteínas Proto-Oncogénicas c-fos
/
Hormonas Peptídicas
/
Conducta Alimentaria
Idioma:
En
Revista:
Peptides
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos