Association between HLA class II locus and the susceptibility to Artemisia pollen-induced allergic rhinitis in Chinese population.
Otolaryngol Head Neck Surg
; 130(2): 192-6, 2004 Feb.
Article
en En
| MEDLINE
| ID: mdl-14990915
ABSTRACT
OBJECTIVE:
The aim of the study was to determine whether susceptibility or resistance to Artemisia pollen-induced allergic rhinitis was associated with HLA class II DQA1, DQB1 loci. Study design and setting Forty-one subjects with allergic rhinitis and 41 healthy controls from Beijing were genotyped at HLA class II DQA1, DQB1 alleles by polymerase chain reaction amplification with sequence-specific primers-based technique.RESULTS:
The allele frequencies of HLA-DQA1*0201, DQB1*0602 were lower in patients with allergic rhinitis compared with the controls (24.39% versus 46.34%, P = 0.038; 4.88% versus 26.83%, P = 0.007), and the frequency of DQA1*0302 was higher among patients than the controls (58.54% versus 14.63%, P = 0.00004, Pc = 0.0004). CONCLUSION ANDSIGNIFICANCE:
HLA-DQA1 and -DQB1 genes may be involved in the development of Artemisia pollen-induced allergic rhinitis. HLA-DQA1*0201, DQB1*0602 alleles may be a protective factor and DQA1*0302 may be a susceptible factor for Artemisia pollen-induced allergic rhinitis.
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Bases de datos:
MEDLINE
Asunto principal:
Polen
/
Antígenos HLA-DQ
/
Rinitis Alérgica Estacional
/
Artemisia
/
Predisposición Genética a la Enfermedad
/
Pueblo Asiatico
Tipo de estudio:
Risk_factors_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
Otolaryngol Head Neck Surg
Año:
2004
Tipo del documento:
Article