Effect of dietary enrichment with n-3 polyunsaturated fatty acids (PUFA) or n-9 PUFA on arachidonate metabolism in vivo and experimentally induced inflammation in mice.
Biol Pharm Bull
; 27(3): 319-23, 2004 Mar.
Article
en En
| MEDLINE
| ID: mdl-14993795
ABSTRACT
Mice were fed a diet supplemented with palm oil (control diet), n-3 polyunsaturated fatty acids (PUFA)-, or n-9 PUFA-rich oil for 3 weeks. The n-3 PUFA-rich diet suppressed the generation of both leukotrienes (LT) and prostaglandins (PG), but the n-9 PUFA-rich diet did LT but not PG generation during acute inflammation. Leukocyte accumulation during acute inflammation was not different in the n-3 or n-9 PUFA-rich diet group as compared with the control group. The n-3 PUFA-rich diet but not the n-9 PUFA-rich diet suppressed Freund's adjuvant-induced granuloma formation. The n-9 PUFA-rich diet significantly attenuated galactosamine/lipopolysaccharide-induced liver injury more effectively than the n-3 PUFA-rich diet as compared with the control diet. The present study revealed the differential modification of experimentally induced inflammation in mice by dietary n-3 PUFA and n-9 PUFA, which may be due to their different effects on 5-lipoxygenease and cyclooxygenase metabolism of arachidonic acid during inflammatory processes.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Triglicéridos
/
Ácido Araquidónico
/
Dieta
/
Ácidos Grasos Insaturados
/
Inflamación
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Biol Pharm Bull
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón