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Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells.
Kim, Hyung-Jin; Jang, Seon Il; Kim, Young-Jun; Chung, Hun-Taeg; Yun, Yong-Gab; Kang, Tai-Hyun; Jeong, Ok-Sam; Kim, Youn-Chul.
Afiliación
  • Kim HJ; Immunopia Research Laboratory of Molecular and Cellular Immunology, Wonkwang University, Iksan 570-749, South Korea.
Fitoterapia ; 75(3-4): 261-6, 2004 Jun.
Article en En | MEDLINE | ID: mdl-15158982
Scopoletin (1-50 microg/ml) inhibited the release of PGE2, TNF-alpha, IL-1beta and IL-6 and suppressed the expression of COX-2 in a concentration-dependent manner. These results suggest that scopoletin might suppress the production of such pro-inflammatory cytokines and exert inhibitory activity on LPS-induced PGE2 production through the depression of COX-2 expression.
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Bases de datos: MEDLINE Medicinas Complementárias: Homeopatia Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Aromoterapia Asunto principal: Escopoletina / Artemisia / Macrófagos / Fitoterapia / Antiinflamatorios Idioma: En Revista: Fitoterapia Año: 2004 Tipo del documento: Article País de afiliación: Corea del Sur
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Bases de datos: MEDLINE Medicinas Complementárias: Homeopatia Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Aromoterapia Asunto principal: Escopoletina / Artemisia / Macrófagos / Fitoterapia / Antiinflamatorios Idioma: En Revista: Fitoterapia Año: 2004 Tipo del documento: Article País de afiliación: Corea del Sur