Anticonvulsant and neurotoxicity evaluation of some 6-substituted benzothiazolyl-2-thiosemicarbazones.
Farmaco
; 60(1): 1-5, 2005 Jan.
Article
en En
| MEDLINE
| ID: mdl-15652361
ABSTRACT
Various 6-substituted benzothiazolyl-2-thiosemicarbazones were synthesized and screened for anticonvulsant activity in maximal electroshock induced seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure models in mice. The neurotoxicity was assessed using the rotorod method. The 6-methyl benzothiazolyl-2-thiosemicarbazones showed anticonvulsant activity in both mice i.p. and rat oral MES screen. The 6-nitro benzothiazolyl thiosemicarbazone derivative 1a emerged as the most promising one with anti-MES activity in mice i.p., rat i.p. and rat p.o. evaluations. All the compounds exhibited lesser or no neurotoxicity compared to phenytoin. The isatinimino derivatives had shown better activity when compared to the benzylidene or acetophenone derivatives.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Convulsiones
/
Tiosemicarbazonas
/
Anticonvulsivantes
Idioma:
En
Revista:
Farmaco
Año:
2005
Tipo del documento:
Article
País de afiliación:
India