Antitumor-promoting activity of coumarins from citrus plants.
Planta Med
; 71(1): 84-7, 2005 Jan.
Article
en En
| MEDLINE
| ID: mdl-15678381
ABSTRACT
In order to identify antitumor-promoting agents, we performed primary in vitro screening of 31 coumarins isolated from 11 plants of the Citrus species (Rutaceae), examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Some of the 8-substituted coumarins, 8-formyl-7-hydroxycoumarin (5), osthenol (7), demethylauraptenol (8), osthenon (9) and dihydroosthenon (10), were found to significantly inhibit EBV-EA activation (IC50 129-207 mol ratio/32 pmol TPA). Osthenol (7) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
/
Plantas_medicinales
Asunto principal:
Citrus
/
Fitoterapia
/
Antineoplásicos Fitogénicos
Idioma:
En
Revista:
Planta Med
Año:
2005
Tipo del documento:
Article
País de afiliación:
Japón