Suppressive effects of dichloromethane fraction from the Areca catechu nut on naloxone-precipitated morphine withdrawal in mice.
Fitoterapia
; 76(6): 534-9, 2005 Sep.
Article
en En
| MEDLINE
| ID: mdl-15993008
ABSTRACT
In the present study, we investigated the effect of the dichloromethane fraction from Areca catechu nut on the severity of naloxone-precipitated morphine withdrawal in morphine-dependent mice. A single intraperitoneal injection of dichloromethane fraction at dose of 125 and 175 mg/kg significantly delayed the onset of withdrawal jumping behavior in a concentration-dependent manner compared to that of saline controls. The dichloromethane fractions also significantly decreased jumping numbers and faecal and urinary excretions during the withdrawal period.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Areca
/
Síndrome de Abstinencia a Sustancias
/
Extractos Vegetales
/
Analgésicos Opioides
/
Fitoterapia
/
Morfina
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Fitoterapia
Año:
2005
Tipo del documento:
Article
País de afiliación:
Tailandia