Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men: a randomized controlled trial.
Arterioscler Thromb Vasc Biol
; 25(9): 1952-9, 2005 Sep.
Article
en En
| MEDLINE
| ID: mdl-16020749
ABSTRACT
OBJECTIVE:
To explore the separate and combined effects of simvastatin and a low-saturated diet rich in alpha-linolenic acid on serum fatty acids. METHODS ANDRESULTS:
120 hypercholesterolemic men were randomly allocated to a habitual diet or dietary treatment group and to receive, in random order, simvastatin 20 mg/d or placebo, each for 12 weeks, in a double-blind manner. Dietary treatment decreased proportions from total fatty acids of palmitic acid (C160) by 3.3% (P<0.05), stearic acid (C180) by 3.7% (P<0.05) and increased proportions of oleic acid (C181n-9) by 4.2% (P<0.01), and alpha-linolenic acid (C183n-3) by 29.8% (P<0.001). Simvastatin decreased proportions from total fatty acids of palmitic acid by 2.0% (P<0.01), linoleic acid (C182n-6) by 5.3% (P<0.001), and alpha-linolenic acid by 6.8% (P<0.05), and increased proportions of gamma-linolenic acid (C183n-6) by 11.1% (P<0.001), dihomo-gamma-linolenic acid (C203n-6) by 4.2% (P<0.01), arachidonic acid (C204n-6) by 14.2% (P<0.001), and the sum of long-chain polyunsaturated fatty acids (C20-22) by 9.0% (P<0.001). Simvastatin increased ratios of stearic to palmitic, gamma-linolenic to linoleic, and arachidonic to dihomo-gamma-linolenic acid by 7.6%, 17.0%, and 10.0% (P<0.001 for all), respectively, suggesting increased fatty acid elongase and Delta6- and Delta5-desaturase enzyme activities.CONCLUSIONS:
Increased formation of long-chain polyunsaturated fatty acids and their metabolites may contribute a substantial part of the pleiotropic effects of simvastatin.
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Bases de datos:
MEDLINE
Asunto principal:
Ácido alfa-Linolénico
/
Simvastatina
/
Hipercolesterolemia
/
Anticolesterolemiantes
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
Arterioscler Thromb Vasc Biol
Año:
2005
Tipo del documento:
Article
País de afiliación:
Finlandia