Nevirapine derivatives with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS.
Biomed Pharmacother
; 59(8): 456-9, 2005 Sep.
Article
en En
| MEDLINE
| ID: mdl-16140495
ABSTRACT
A series of nevirapine derivatives has been synthesized in an effort to enhance the spectrum of chemotherapeutic properties for the effective treatment of AIDS and AIDS-related opportunistic infections. The nevirapine derivative bearing isoniazid moiety (3a) was found to be the most potent compound with EC50 of<0.0636 microM, CC50 of>1000 microM and selectivity index of>15,723 which also exhibited 90% inhibition against Mycobacterium tuberculosis at 6.25 microg/ml. Compound 3c showed 100% inhibition against M. tuberculosis and also exhibited potent antibacterial activity against 24 pathogenic bacteria with MIC less than 1 microg/ml.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Plantas_medicinales
Asunto principal:
VIH-1
/
Fármacos Anti-VIH
/
Nevirapina
/
Antibacterianos
/
Mycobacterium tuberculosis
Idioma:
En
Revista:
Biomed Pharmacother
Año:
2005
Tipo del documento:
Article
País de afiliación:
India