Your browser doesn't support javascript.
loading
Hypothalamic nitric oxide synthase in affective disorder: focus on the suprachiasmatic nucleus.
Bernstein, H G; Heinemann, A; Krell, D; Dobrowolny, H; Bielau, H; Keilhoff, G; Bogerts, B.
Afiliación
  • Bernstein HG; Department of Psychiatry, University of Magdeburg, Leipziger Str.44, D-39120 Magdeburg, Germany. Hans-Gert.Bernstein@medizin.uni-magdeburg.de
Cell Mol Biol (Noisy-le-grand) ; 51(3): 279-84, 2005 Sep 05.
Article en En | MEDLINE | ID: mdl-16191395
Depression is frequently associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, which leads to repeated episodes of hypercortisolemia. Hypothalamic paraventricular neurons are believed to trigger these processes by aberrant generation and/or release of corticotropin releasing hormone, oxytocin, vasopressin, and nitric oxide (NO). Recent findings from two independent laboratories have demonstrated that the suprachiasmatic nucleus, which in part controls the cellular activity of paraventricular neurons (PVN), is also involved in affective disorder. The aim of the present study was to elucidate by stereological analysis, whether suprachiasmatic nucleus (SCN) nitric oxide synthase and neurophysin generating neurons are affected in neuropsychiatric disorders. We show that compared to controls the number of nitric oxide synthase immunoreactive neurons is greatly reduced both in depression and in schizophrenia. In subjects with affective disorder there was a correlation between the number of NOS-expressing cells and duration of treatment with antidepressants. The number of neurophysin-expressing SCN neurons was also fewer in cases with mood disorder. It is concluded that SCN-derived NO may be a relevant pathophysiological factor in neuropsychiatric disorders.
Asunto(s)
Buscar en Google
Bases de datos: MEDLINE Asunto principal: Núcleo Supraquiasmático / Neurofisinas / Óxido Nítrico Sintasa / Trastornos del Humor / Hipotálamo / Neuronas Idioma: En Revista: Cell Mol Biol (Noisy-le-grand) Año: 2005 Tipo del documento: Article País de afiliación: Alemania
Buscar en Google
Bases de datos: MEDLINE Asunto principal: Núcleo Supraquiasmático / Neurofisinas / Óxido Nítrico Sintasa / Trastornos del Humor / Hipotálamo / Neuronas Idioma: En Revista: Cell Mol Biol (Noisy-le-grand) Año: 2005 Tipo del documento: Article País de afiliación: Alemania