Synergistic effects of atenolol and amlodipine for lowering and stabilizing blood pressure in 2K1C renovascular hypertensive rats.
Acta Pharmacol Sin
; 26(11): 1303-8, 2005 Nov.
Article
en En
| MEDLINE
| ID: mdl-16225751
ABSTRACT
AIM:
To test the synergistic effects of atenolol and amlodipine on lowering blood pressure (BP) and reducing blood pressure variability (BPV) in 2-kidney, one-clip (2K1C) renovascular hypertensive rats.METHODS:
Forty-eight 2K1C renovascular hypertensive rats were randomly divided into 6 groups. They were respectively given 0.8% carboxymethylcellulose sodium (control), atenolol (10.0 mg/kg), amlodipine (1.0 mg/kg), and combined atenolol and amlodipine (low dose 5.0+0.5 mg/kg; intermediate dose 10.0+1.0 mg/kg; high dose 20.0+2.0 mg/kg). The drugs were given via a catheter in a gastric fistula. BP was recorded for 25 h from 1 h before drug administration to 24 h after administration.RESULTS:
Compared with BP before medication, all 3 doses of combined atenolol and amlodipine significantly decreased the BP at 24 h after administration, except for the low dose on diastolic BP. Compared with the control group, all 3 doses of combined atenolol and amlodipine significantly reduced the average BP levels for the 24 h period after administration; furthermore, the high and intermediate doses also significantly decreased the BPV levels for the same period. The q values calculated by probability sum analysis for systolic and diastolic BP for the 24 h period after administration were 2.29 and 1.45, respectively, and for systolic and diastolic BPV for the same period they were 1.41 and 1.60, respectively.CONCLUSION:
There is significant synergism between atenolol and amlodipine in lowering and stabilizing BP in 2K1C renovascular hypertensive rats.
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Bases de datos:
MEDLINE
Asunto principal:
Atenolol
/
Presión Sanguínea
/
Amlodipino
/
Hipertensión Renovascular
/
Antihipertensivos
Idioma:
En
Revista:
Acta Pharmacol Sin
Año:
2005
Tipo del documento:
Article
País de afiliación:
China