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Role of exposure to radon and silicosis on the cell type of lung carcinoma in German uranium miners.
Taeger, Dirk; Fritsch, Arno; Wiethege, Thorsten; Johnen, Georg; Eisenmenger, Andreas; Wesch, Horst; Ko, Yon; Stier, Sebastian; Michael Muller, Klaus; Bruning, Thomas; Pesch, Beate.
Afiliación
  • Taeger D; Berufsgenossenschaftliches Forschungsinstitut fur Arbeitsmedizin (BGFA), Institute of Ruhr University of Bochum, Germany. taeger@bgfa.de
Cancer ; 106(4): 881-9, 2006 Feb 15.
Article en En | MEDLINE | ID: mdl-16411224
ABSTRACT

BACKGROUND:

In East Germany, uranium mining was undertaken on a large scale from 1946 to 1990. Poor working conditions led to a high level of exposure to ionizing radiation and quartz dust. This analysis evaluates the histopathology of lung carcinoma in uranium miners in relation to radon exposure and silicosis.

METHODS:

A database developed for autopsy cases ascertained in a pathological tissue repository of German uranium miners was used to estimate odds ratios for developing lung carcinoma by major cell type with regard to radon exposure and silicosis. Silicosis information was extracted from autopsy protocols. Working level months (WLM) were calculated with a job-exposure matrix to assess lifetime radon exposure. Risk estimates were based on 3414 male miners who died from small cell lung carcinoma (SCLC, n = 1446), squamous cell carcinoma (SqCC, n = 1006), or adenocarcinoma (AC, n = 962) between 1957 and 1990.

RESULTS:

SCLC and SqCC seem more likely to be associated with high radon exposure than AC. Mean cumulative radon exposure was 868 (SD 631) WLM in SCLC, 871 (SD 652) WLM in SqCC, and 743 (SD 598) WLM in AC. Silicosis prevalence was 26% in SCLC, 38% in SqCC, and 30% in AC. In silicotics, AC and SqCC had a relatively higher frequency at the expense of SCLC. SCLC occurred earlier than AC and SqCC.

CONCLUSION:

High radon exposure was associated with a higher relative frequency of SCLC and SqCC than AC. Silicosis tended to increase the appearance of SqCC and AC.
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Bases de datos: MEDLINE Asunto principal: Silicosis / Carcinoma de Células Escamosas / Exposición Profesional / Radón / Carcinoma de Células Pequeñas / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies País/Región como asunto: Europa Idioma: En Revista: Cancer Año: 2006 Tipo del documento: Article País de afiliación: Alemania
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Bases de datos: MEDLINE Asunto principal: Silicosis / Carcinoma de Células Escamosas / Exposición Profesional / Radón / Carcinoma de Células Pequeñas / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies País/Región como asunto: Europa Idioma: En Revista: Cancer Año: 2006 Tipo del documento: Article País de afiliación: Alemania