Transcranial imaging of audiogenic epileptic foci in the cortex of DBA/2J mice.
Neuroreport
; 17(3): 267-71, 2006 Feb 27.
Article
en En
| MEDLINE
| ID: mdl-16462595
ABSTRACT
Exposure to intense sound stimuli induces audiogenic seizures in DBA/2J mice. We investigated cortical activities during sound stimulation using flavoprotein fluorescence imaging. Most DBA/2J mice had seizures during intense sound stimulation, with more than half surviving after seizures. Surviving mice were anesthetized with urethane (1.6 g/kg, intraperitoneal), and the skull was exposed and then covered with clear resin. More than 3 days after surgery, the mice were lightly anesthetized with urethane (0.8 g/kg) and cortical activities during intense sound stimulation were visualized. Focal responses appeared near the somatosensory cortex together with spike activities localized in the response area. These findings indicate that epileptic foci of audiogenic seizure are formed in the cortex of DBA/2J mice.
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Bases de datos:
MEDLINE
Asunto principal:
Corteza Somatosensorial
/
Estimulación Acústica
/
Mapeo Encefálico
/
Diagnóstico por Imagen
/
Epilepsia Refleja
/
Potenciales Evocados Auditivos
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Revista:
Neuroreport
Año:
2006
Tipo del documento:
Article
País de afiliación:
Japón