Enantioconvergent hydrolysis of styrene epoxides by newly discovered epoxide hydrolases in mung bean.
Org Lett
; 8(8): 1737-40, 2006 Apr 13.
Article
en En
| MEDLINE
| ID: mdl-16597154
ABSTRACT
[reaction see text] Two novel epoxide hydrolases were discovered in mung bean (Phaseolus radiatus L.) for the first time, either of which can catalyze enantioconvergent hydrolysis of styrene epoxides. Their regioselectivity coefficients are more than 90% for the p-nitrostyrene oxide. Furthermore, the crude mung bean powder was also shown to be a cheap and practical biocatalyst, allowing a one-step asymmetric synthesis of chiral (R)-diols from racemic epoxides, in up to >99% ee and 68.7% overall yield (after recrystallization).
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Plantas Medicinales
/
Estireno
/
Epóxido Hidrolasas
/
Compuestos Epoxi
/
Fabaceae
Idioma:
En
Revista:
Org Lett
Año:
2006
Tipo del documento:
Article
País de afiliación:
China