Polyunsaturated fatty acid intake is adversely related to liver function in HIV-infected subjects: the THUSA study.
Am J Clin Nutr
; 83(5): 1193-8, 2006 May.
Article
en En
| MEDLINE
| ID: mdl-16685065
ABSTRACT
BACKGROUND:
Dietary fat intake in the South African population is increasing. This population also has a high prevalence of HIV infection. However, information about metabolic effects of dietary fatty acids on HIV-infected subjects is lacking.OBJECTIVE:
Our objective was to investigate the relation between dietary fatty acid intake and liver function in HIV-infected compared with HIV-uninfected subjects.DESIGN:
This cross-sectional epidemiologic survey included a representative sample of 1854 apparently healthy black volunteers aged > or =15 y, who were recruited from 37 randomly selected sites throughout the North West province of South Africa. Data from 216 asymptomatic HIV-infected and 1604 HIV-uninfected subjects were used.RESULTS:
Intakes of polyunsaturated fatty acids (PUFAs), linoleic acid (n-6), and the ratio of PUFAs to saturated fatty acids (SFAs) were positively associated with all the liver enzymes measured in HIV-infected subjects (R = 0.16-0.65). Most of these R values differed significantly from the R values for HIV-uninfected subjects. No associations were seen between liver enzymes and intakes of SFAs and monounsaturated fatty acids. Vitamin E intake was positively associated with serum gamma-glutamyl transpeptidase (R = 0.23), alanine aminotransferase (R = 0.37), and aspartate aminotransferase (R = 0.58) in HIV-infected subjects; these correlations differed significantly from those of the HIV-uninfected subjects because PUFA sources are the main carriers of vitamin E.CONCLUSIONS:
The results suggest that n-6 PUFA intakes may be related to liver damage in these HIV-infected asymptomatic subjects. The reasons or mechanisms responsible are not clear, and further research is necessary to determine the optimal safe amounts for intake of n-6 PUFAs by HIV-infected subjects, especially in countries with traditionally high intakes of n-6 PUFA-rich vegetable oils.
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Bases de datos:
MEDLINE
Asunto principal:
Grasas de la Dieta
/
Infecciones por VIH
/
Ácidos Grasos Insaturados
/
Hepatopatías
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
País/Región como asunto:
Africa
Idioma:
En
Revista:
Am J Clin Nutr
Año:
2006
Tipo del documento:
Article