Radical scavenging activity of ribonuclease inhibitor from cow placenta.
Biochemistry (Mosc)
; 71(5): 520-4, 2006 May.
Article
en En
| MEDLINE
| ID: mdl-16732730
ABSTRACT
Cow placenta ribonuclease inhibitor (CPRI) has been purified 5062-fold by affinity chromatography, the product being homogeneous by sodium dodecyl sulfate-gel electrophoresis. The chemiluminescence technique was used to determine the radical scavenging activities of CPRI toward different reactive oxygen species (ROS) including superoxide anion (O2-*), hydroxyl radical (OH*), lipid-derived radicals (R*), and singlet oxygen (1O2). CPRI could effectively scavenge O2-*, OH*, R*, and 1O2 at EC50 of 0.12, 0.008, 0.009, and 0.006 mg/ml, respectively. In addition, the radical scavenging activities of CPRI were higher than those of tea polyphenols, indicating that CPRI is a powerful antioxidant.
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Bases de datos:
MEDLINE
Asunto principal:
Placenta
/
Hormonas Placentarias
/
Depuradores de Radicales Libres
Idioma:
En
Revista:
Biochemistry (Mosc)
Año:
2006
Tipo del documento:
Article