[Studies on chemical constituents in root of Phlomis medicinalis I].

ABSTRACT

OBJECTIVE: To study the chemical constituents in root of Phlomis medicinalis. METHOD: The compounds were isolated and repeatedly purified on macroporous resin, silica gel column chromatography, TLC and Prep-HPLC and the structures were elucidated by physico-chemical properties and NMR spectra. RESULT: Eight compounds were obtained and elucidated as 5-Hydroxy-7-methoxy-4, 6-dimethylphthalide (1), 4-hydroxymethyl-2-furaldehyde (2) and six iridoid glucosides 6-O-acetyl-shanzhiside methyl ester (3), 8-O-acetyl-shanzhiside methyl ester (4), shanzhiside methyl ester (5), sesamoside (6), phloyoside II (7) and dehydropentstemoside (8). CONCLUSION: All the compounds were isolated from the plant for the first time and 1 and 3 were obtained from the plants of Phlomis for the first time.