Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children.
J Nutr
; 136(10): 2600-5, 2006 Oct.
Article
en En
| MEDLINE
| ID: mdl-16988133
ABSTRACT
The impact of vitamin A supplementation on childhood diarrhea may be determined by the regulatory effect supplementation has on the mucosal immune response in the gut. Previous studies have not addressed the impact of vitamin A supplementation on the production of monocyte chemoattractant protein 1 (MCP-1), an essential chemokine involved in pathogen-specific mucosal immune response. Fecal MCP-1 concentrations, determined by an enzyme-linked immuno absorption assay, were compared among 127 Mexican children 5-15 mo of age randomized to receive a vitamin A supplement (<12 mo of age, 20,000 IU of retinol; > or =12 mo, 45,000 iu) every 2 mo or a placebo as part of a larger vitamin A supplementation trial. Stools collected during the summer months were screened for MCP-1 and gastrointestinal pathogens. Values of MCP-1 were categorized into 3 levels (nondetectable,
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Bases de datos:
MEDLINE
Asunto principal:
Vitamina A
/
Quimiocina CCL2
/
Diarrea
/
Intestinos
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
/
Risk_factors_studies
País/Región como asunto:
Mexico
Idioma:
En
Revista:
J Nutr
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos