Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats.
Biol Pharm Bull
; 30(2): 363-6, 2007 Feb.
Article
en En
| MEDLINE
| ID: mdl-17268081
ABSTRACT
In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (gamma-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.
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Bases de datos:
MEDLINE
Medicinas Complementárias:
Homeopatia
Asunto principal:
Valeriana
/
Rhodiola
/
Glutamatos
/
Hipnóticos y Sedantes
/
Trastornos del Inicio y del Mantenimiento del Sueño
Idioma:
En
Revista:
Biol Pharm Bull
Año:
2007
Tipo del documento:
Article
País de afiliación:
Japón