N-Hydroxythiosemicarbazones: synthesis and in vitro antitubercular activity.
Bioorg Med Chem Lett
; 17(7): 1888-91, 2007 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-17276683
ABSTRACT
N-Hydroxythiosemicarbazide was prepared by two methods starting from 2,4-dimethoxy benzyl amine and hydroxylamine hydrochloride, which in turn was reacted with various aldehydes and ketones to obtain the titled compounds. Eighteen compounds were tested for their in vitro activity against Mycobacterium tuberculosis H37Rv using the agar dilution method. Compound 10p was found to be the most potent compound (MIC 0.28 microM) and was 2.5 times more active than standard isoniazid.
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Bases de datos:
MEDLINE
Asunto principal:
Semicarbacidas
/
Semicarbazonas
/
Química Farmacéutica
/
Mycobacterium tuberculosis
/
Antituberculosos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Año:
2007
Tipo del documento:
Article
País de afiliación:
India