Bisphosphonate-related osteonecrosis of the jaws: a report of three cases demonstrating variability in outcomes and morbidity.
J Am Dent Assoc
; 138(5): 602-9, 2007 May.
Article
en En
| MEDLINE
| ID: mdl-17473037
ABSTRACT
BACKGROUND:
Bisphosphonates are used widely to manage skeletal disorders resulting from malignancies that destroy bone and from some metabolic bone diseases. A strong association between bisphosphonate treatment and the appearance of painful exposed nonvital bone in the mandible and maxilla after oral surgery has been reported in the last decade. Extensive reviews have appeared in the dental literature regarding bisphosphonate-related osteonecrosis of the jaws (BRONJ), including protocols for diagnosis, management and diagnostic imaging for early detection; feature definition; and determination of extent of the disease. CASE DESCRIPTION The authors provide three case reports to show the contrast in treatment outcomes and morbidity in patients with BRONJ. The cases involved diagnostic imaging modalities commonly used in the practice of dentistry panoramic radiography and cone-beam volumetric computed tomography. CLINICAL IMPLICATIONS These case reports demonstrate the usefulness of dental diagnostic imaging in the detection and management of BRONJ, corroborate the increasing number of reports regarding high levels of morbidity associated with various BRONJ treatments, and underscore the danger of performing invasive dental procedures for patients receiving bisphosphonate therapy.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Oxigenoterapia_hiperbrica
Asunto principal:
Osteonecrosis
/
Enfermedades Maxilomandibulares
/
Difosfonatos
/
Conservadores de la Densidad Ósea
Tipo de estudio:
Etiology_studies
/
Guideline
/
Screening_studies
Idioma:
En
Revista:
J Am Dent Assoc
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos