Agaritine and its derivatives are potential inhibitors against HIV proteases.
Med Chem
; 3(3): 221-6, 2007 May.
Article
en En
| MEDLINE
| ID: mdl-17504192
ABSTRACT
Agaritine, or beta-N-[gamma-L(+)-glutamyl]-4-hydroxymethylphenylhydrazine, is a Chinese herbal medicine, known having the antiviral and anticancer function. However, so far no reports whatsoever have been made for its potential as an anti-HIV agent. It was observed by docking experiments for more than 9,000 compounds extracted from various Chinese medicines that the compound agaritine distinguished itself from all the others in binding to the HIV protease with the most favorable free energy. Based on this, a series of derivatives were generated by modifying agaritine. It has been observed thru an extensive docking study that some of agaritine derivatives had markedly stronger binding interaction with the HIV protease than agaritine, suggesting that these derivatives might be good candidates for developing drugs for AIDS therapy.
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Bases de datos:
MEDLINE
Asunto principal:
Fenilhidrazinas
/
Simulación por Computador
/
Inhibidores de la Proteasa del VIH
Idioma:
En
Revista:
Med Chem
Año:
2007
Tipo del documento:
Article
País de afiliación:
China