A comparison of topical chlorhexidine, ciprofloxacin, and fortified tobramycin/cefazolin in rabbit models of Staphylococcus and Pseudomonas keratitis.
J Ocul Pharmacol Ther
; 23(3): 213-20, 2007 Jun.
Article
en En
| MEDLINE
| ID: mdl-17593004
ABSTRACT
AIMS:
Chlorhexidine was evaluated as a potential topical therapy for experimental bacterial keratitis.METHODS:
Chlorhexidine (0.01%) was compared to ciprofloxacin (0.3%) and tobramycin (1.36%)/cefazolin (5%) both in vitro and in vivo for the treatment of Staphylococcus aureus and Pseudomonas aeruginosa infections. The minimum inhibitory concentration (MIC) was established for each organism for each antibiotic, using a standardized method. One thousand (1000) colony-forming units (CFU) of S. aureus or P. aeruginosa was intrastromally injected into rabbit cornea. A total of 92 corneas were infected and then treated topically with antibiotics. The control eyes were treated with artificial tears. The rabbits were later sacrificed, and the corneal buttons were harvested.RESULTS:
The MIC for chlorhexidine wasCONCLUSIONS:
Chlorhexidine short-term treatment was an effective topical therapy for bacterial keratitis in the rabbit model, when compared with ciprofloxacin and tobramycin/cefazolin, in particular for S. aureus.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
/
Plantas_medicinales
Asunto principal:
Infecciones por Pseudomonas
/
Infecciones Estafilocócicas
/
Infecciones Bacterianas del Ojo
/
Queratitis
/
Antiinfecciosos Locales
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Ocul Pharmacol Ther
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos