Ursodeoxycholic acid treatment in preterm infants: a pilot study for the prevention of cholestasis associated with total parenteral nutrition.
J Pediatr Gastroenterol Nutr
; 46(2): 228-31, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-18223390
ABSTRACT
In a prospective, double-blind, placebo-controlled trial, the efficacy and safety of ursodeoxycholic acid (UDCA) was evaluated in preterm infants, in terms of its potential impact on fat absorption, advancement of enteral feeding, development of cholestasis, growth, nutritional status, and metabolic status. Although fecal fat excretion slightly decreased and achievement of full enteral feeding was earlier in the UDCA group, these differences were not significant. Interestingly, whereas serum gamma-glutamyl transferase activity increased during the parenteral nutrition period in the placebo group, we observed a constant and significant decrease in the UDCA group. This observation warrants further investigation to determine the utility of prophylactic UDCA in preventing cholestasis in infants with prolonged parenteral nutrition.
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Trofoterapia
Asunto principal:
Ácido Ursodesoxicólico
/
Recien Nacido Prematuro
/
Colagogos y Coleréticos
/
Colestasis
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Nutrición Parenteral Total
/
Emulsiones Grasas Intravenosas
Tipo de estudio:
Clinical_trials
/
Observational_studies
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Año:
2008
Tipo del documento:
Article
País de afiliación:
Italia