A patient with anti-aquaporin 4 antibody who presented with recurrent hypersomnia, reduced orexin (hypocretin) level, and symmetrical hypothalamic lesions.
Sleep Med
; 10(2): 253-5, 2009 Feb.
Article
en En
| MEDLINE
| ID: mdl-18226957
ABSTRACT
Recent studies have demonstrated that hypothalamic lesions associated with brain tumor, head trauma, and encephalopathy can cause symptomatic hypersomnia with a reduced orexin (hypocretin) level in the cerebrospinal fluid (CSF). Aquaporin 4 (AQP4), a member of the AQP superfamily, is strongly expressed in the hypothalamus in which orexin (hypocretin)-containing neurons are primarily concentrated. We report the case of a patient with a serum anti-AQP4 antibody who presented with recurrent hypersomnia, symmetrical hypothalamic lesions with long spinal cord lesions on MRI, and a reduced CSF orexin (hypocretin) level, all of which were improved simultaneously by steroid therapy. Further studies should be performed to determine the roles of anti-AQP4 antibody positivity in patients with hypersomnia associated with orexin (hypocretin) deficiency and hypothalamic lesions.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neuropéptidos
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Péptidos y Proteínas de Señalización Intracelular
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Acuaporina 4
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Trastornos de Somnolencia Excesiva
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Hipotálamo
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Anticuerpos
Idioma:
En
Revista:
Sleep Med
Año:
2009
Tipo del documento:
Article
País de afiliación:
Japón