Biomechanical analysis of combined treatment of high calcium and bisphosphonate in tibia of steroid-treated growing-phase rats.
Dent Mater J
; 27(5): 647-53, 2008 Sep.
Article
en En
| MEDLINE
| ID: mdl-18972779
ABSTRACT
Childhood systemic diseases are commonly treated with steroids. Consequently, steroid-induced osteoporosis is often observed as a side effect of steroid therapy. However, osteoporosis of tibia resulting from steroid therapy has not been reported yet. Herein we constructed a steroid-induced osteoporosis in tibia of the growing phase rats to examine internal structural changes of the bone and tried to find out the effect of bisphosphonates as a new and early treatment method. Biomechanical analysis was performed using two-dimensional microdensitometry and three-dimensional pQCT method. In addition, the following evaluations were carried out noninvasive bone strength measurements in steroid-induced osteoporotic rat tibiae; comparing the effectiveness of single high-calcium diet versus combined treatment of high calcium and bisphosphonate for osteoporosis; and quantitative measurement of four elements (Ca, P, Mg, Zn) in bone matrix. Our data suggested that a combined treatment of high calcium and bisphosphonate was an effective new method to improve and treat steroid-induced osteoporosis in childhood.
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Bases de datos:
MEDLINE
Asunto principal:
Osteoporosis
/
Tibia
/
Desarrollo Óseo
/
Prednisona
/
Calcio de la Dieta
/
Ácido Etidrónico
/
Conservadores de la Densidad Ósea
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Dent Mater J
Año:
2008
Tipo del documento:
Article
País de afiliación:
Japón