In vivo protective effect of crocetin on benzo(a)pyrene-induced lung cancer in Swiss albino mice.
Phytother Res
; 23(4): 533-9, 2009 Apr.
Article
en En
| MEDLINE
| ID: mdl-19067387
ABSTRACT
The objective of this investigation was to determine the efficacy of crocetin in preventing lung tumorigenesis in mice. We evaluated crocetin in Swiss albino mice treated with the tobacco-specific carcinogen benzo(a)pyrene [B(a)P] for their ability to inhibit pulmonary adenoma formation and growth. Male Swiss albino mice (7 weeks old) were given 100 mg/kg B(a)P by i.p. injection, and 4 or 14 weeks later, they were given crocetin 50 mg/kg by i.p. injection 3 days/week. Crocetin (50 mg/kg body weight) reduced proliferating cells by 68% and 45% in 18 and 8 weeks of treatment respectively. The levels of glycoproteins and polyamines were significantly altered in the B(a)P-induced animals than in crocetin treatment groups. The activity of crocetin was more pronounced in the cancer. Taken together, these results indicate that crocetin was capable of inhibiting proliferation cells by inhibiting proliferating cells, glycoprotein and polyamine synthesis.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Carotenoides
/
Adenoma
/
Neoplasias Pulmonares
/
Antineoplásicos Fitogénicos
Idioma:
En
Revista:
Phytother Res
Año:
2009
Tipo del documento:
Article
País de afiliación:
India