Antinociceptive effects of 14-membered cyclopeptide alkaloids.
J Nat Prod
; 72(4): 608-12, 2009 Apr.
Article
en En
| MEDLINE
| ID: mdl-19231884
The analgesic potential of six 14-membered-ring cyclopeptide alkaloids, namely, franganine (1), discarine B (2), scutianines B (3), C (4), and D (5), and adouetine X (6), have been investigated. Among the compounds tested, only franganine (1) and adouetine X (6) produced antinociceptive effects in a mouse model of acute pain, without inducing undesirable side effects. Furthermore, compound 6 also exhibited a pronounced analgesic effect in a chronic neuropathic pain model in mice. It has been found that adouetine X (6) can decrease the activities of Ca(2+)-ATPase and Na(+)/K(+)-ATPase in vitro. Thus, the present findings have demonstrated that adouetine X (6) is a promising analgesic agent.
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Péptidos Cíclicos
/
Plantas Medicinales
/
ATPasas Transportadoras de Calcio
/
ATPasa Intercambiadora de Sodio-Potasio
/
Malvaceae
/
Rhamnaceae
/
Alcaloides
/
Analgésicos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Nat Prod
Año:
2009
Tipo del documento:
Article
País de afiliación:
Brasil