[Primary study on the hepatotoxicity and nephrotoxicity of rats induced by three kinds of nanomaterials].

OBJECTIVE: To investigate the effects of hepatotoxicity and nephrotoxicity on rats induced by Nano-SiO2 Nano-Fe3O4 and SWCNTs. METHODS: 42 Wistar rats were randomly divided into the control group, low and high dose groups of three kinds of nanoparticles. The rats were killed when rats were exposed by oral gavage for 4 weeks. The ratios of liver and kidney to body weight, the pathological changes of liver and kidney, serum certain biochemically indexes were detected. RESULTS: The ratios of liver and kidney to body weight in experimental groups were not significantly difference in comparison to the control. The ALT and AST level in serum of rats in part experiment groups were more higher than those of the control group. The results of pathological analysis indicated that there were small amounts inflammatory cell infiltration and hepatic cell adipose degeneration in the liver of rats in high-dose group, the change of kidney were not found. CONCLUSION: Three kinds of nanoparticles could induce hepatotoxicity of the rats in the condition of this experiment.