Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children.
Clin Exp Allergy
; 39(6): 875-82, 2009 Jun.
Article
en En
| MEDLINE
| ID: mdl-19522996
ABSTRACT
BACKGROUND:
Vitamin D is known to have a number of immunological effects and it may play a role in preventing allergic diseases. Objectives To study the effect of maternal intake of vitamin D during pregnancy on the emergence of asthma, allergic rhinitis (AR), and atopic eczema by the age of 5 years in children with HLA-DQB1-conferred susceptibility for type 1 diabetes.METHODS:
Children (1669) participating in the population-based birth cohort study were followed for asthma, AR, and atopic eczema assessed by validated questionnaire at 5 years. Maternal diet was assessed by a food-frequency questionnaire.RESULTS:
The mean maternal intake of vitamin D was 5.1 (SD 2.6) microg from food and 1.4 (2.6) microg from supplements. Only 32% of the women were taking vitamin D supplements. When adjusted for potential confounders, maternal intake of vitamin D from food was negatively related to risk of asthma [hazard ratio (HR) 0.80; 95% confidence interval (CI) 0.64-0.99] and AR [HR 0.85; 95% CI 0.75-0.97]. Vitamin D supplements alone were not associated with any outcome. Adjustment for maternal intake of other dietary factors did not change the results.CONCLUSION:
Maternal vitamin D intake from foods during pregnancy may be negatively associated with risk of asthma and AR in childhood.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Asma
/
Vitamina D
/
Rinitis Alérgica Perenne
/
Rinitis Alérgica Estacional
/
Suplementos Dietéticos
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
País/Región como asunto:
Europa
Idioma:
En
Revista:
Clin Exp Allergy
Año:
2009
Tipo del documento:
Article
País de afiliación:
Finlandia