[Study on the optimal extracion craft of Xiaochuang gel by central composite design-response surface methodology].

OBJECTIVE: To optimize the extraction craft of Xiaochuang gel by central composite design-response surface methodology. METHODS: The main influential factors of extraction effect included the quantity of ethanol, the concentration of ethanol and the extraction time. The conditions of the extraction were evaluated by the yield of the extracts and the total content of rheum emodin and chrysophanol. The optimal extraction craft of Xiaochuang gel was chosen by central composite design-response surface methodology. RESULTS: The optimal conditions were extracting two times, two hours each time with ten volume multiples of 60% ethanol. CONCLUSIONS: It is simple, convenient and highly predictive to optimize the extraction craft of Xiaochuang gel by central composite design-response surface methodology.