Total synthesis of (+/-)-kellermanoldione: stepwise cycloaddition of a functionalized diene and allenoate.
Org Lett
; 11(17): 3882-5, 2009 Sep 03.
Article
en En
| MEDLINE
| ID: mdl-19655733
The total synthesis of the diterpene kellermanoldione 1 is reported. Stepwise [4 + 2] cycloaddition of the ketal diene 8 and the allenoate 3 afforded the exo adduct 10x as the major product. It was converted into 1 via six steps, among them a key nonconjugative hydrolysis of a gamma-methylene silyl enol ether.
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Diterpenos
Idioma:
En
Revista:
Org Lett
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos