Association of low serum 25-hydroxyvitamin D levels and high arterial blood pressure in the elderly.
Nephrol Dial Transplant
; 25(2): 503-9, 2010 Feb.
Article
en En
| MEDLINE
| ID: mdl-19749143
ABSTRACT
BACKGROUND:
Vitamin D and calcium metabolism are involved in vascular smooth muscle cell proliferation, endothelial function and blood pressure (BP) regulation. Their physiopathology has been a matter of intensive clinical investigation with variable and sometimes contradictory results. Vitamin D insufficiency is highly prevalent in the general population, particularly among the elderly. We evaluated the association between serum 25(OH)-D levels and arterial BP in this population.METHODS:
An epidemiological cross-sectional study was designed to analyse the prevalence of hypovitaminosis D ('D'AVIS' study) in our reference area. The study was performed on a representative random sample of the population over 64 years of age obtained from five primary health care areas. A medical record, arterial BP and biologicalanalysis:
serum 25(OH)-D, iPTH, creatinine, urea, calcium, albumin were obtained.RESULTS:
A total of 237 subjects (53% women), aged between 64 and 93 (mean 71.7 +/- 5.3), were evaluated. The mean serum 25(OH)-D levels were 17.21 +/- 7.57 ng/ml (interval 5-54; 86% had <25 ng/ml). The mean BP was 138.8 +/- 14/80 +/- 7.4 mmHg, and 46% were on antihypertensive treatment. A significant negative association was observed between serum 25(OH)-D levels and systolic (r = -0.153, P = 0.018) and diastolic BP (r = -0.152, P = 0.019). This association persisted after controlling for possible confounders in the multivariate analyses.CONCLUSIONS:
Low serum 25(OH)-D levels were inversely and independently associated with BP. Supplemental measures to prevent hypovitaminosis D in this population would be important, not only to protect the skeletal system but also for the possible beneficial effects on the cardiovascular system and the BP regulation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Vitamina D
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Deficiencia de Vitamina D
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Hipertensión
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Idioma:
En
Revista:
Nephrol Dial Transplant
Año:
2010
Tipo del documento:
Article
País de afiliación:
España