Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.
Food Chem Toxicol
; 48(2): 686-96, 2010 Feb.
Article
en En
| MEDLINE
| ID: mdl-19948201
ABSTRACT
The association of kava products with liver-related health risks has prompted regulatory action in many countries. We used a genome-wide gene expression approach to generate global gene expression profiles from the livers of male B6C3F1 mice administered kava extract by gavage for 14 weeks, and identified the differentially expressed drug metabolizing genes in response to kava treatments. Analyses of gene functions and pathways reveal that the levels of significant numbers of genes involving drug metabolism were changed and that the pathways involving xenobiotics metabolism, Nrf2-mediated oxidative stress response, mitochondrial functions and others, were altered. Our results indicate that kava extract can significantly modulate drug metabolizing enzymes, potentially leading to herb-drug interactions and hepatotoxicity.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Inactivación Metabólica
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Regulación Enzimológica de la Expresión Génica
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Kava
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Perfilación de la Expresión Génica
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Sistema Enzimático del Citocromo P-450
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Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Food Chem Toxicol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos