Acylation stimulating protein is higher in Inuit from Nunavik compared to a southern Quebec population.
Int J Circumpolar Health
; 68(5): 421-32, 2009 Dec.
Article
en En
| MEDLINE
| ID: mdl-20044961
ABSTRACT
OBJECTIVES:
The Inuit of Nunavik in northern Quebec have a lower risk for ischemic heart disease (IHD) compared to Caucasian populations. Acylation stimulating protein (ASP), which is involved in the storage of dietary fat, may play a role. The objective of the study was to determine plasma concentration of ASP in an Inuit and a southern Quebec Caucasian population. STUDYDESIGN:
This is a cross-sectional study evaluating the relationship between ASP and dietary factors, such as retinol, whose intake is higher in the Inuit. As well, concentrations of ASP were evaluated in relationship to components of the metabolic syndrome.METHODS:
Medical history was collected via a questionnaire and anthropometric measurements and blood samples were collected.RESULTS:
ASP was significantly higher in both the Inuit men and women compared to Caucasian men (66.1 +/- 4.1 nM vs 27.5 +/- 2.5 nM, p < 0.0001) and women (71.8 +/- 3.8 nM vs 29.4 +/- 1.3 nM, p < 0.0001). In addition, ASP significantly correlated with total retinol (r = 0.17, p = 0.02) and free retinol (r = 0.15, p = 0.04) in Inuit men but not with other distinctive dietary markers such as omega-3 fatty acids.CONCLUSIONS:
Inuit men and women have higher ASP which was unrelated to the number of risk factors for IHD that were present.
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Bases de datos:
MEDLINE
Asunto principal:
Vitamina A
/
Isquemia Miocárdica
/
Péptidos y Proteínas de Señalización Intercelular
/
Adipoquinas
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Int J Circumpolar Health
Año:
2009
Tipo del documento:
Article
País de afiliación:
Canadá