Effect of alpha-tocopherol and beta-carotene supplementation on macrovascular complications and total mortality from diabetes: results of the ATBC Study.
Ann Med
; 42(3): 178-86, 2010 Apr.
Article
en En
| MEDLINE
| ID: mdl-20350251
ABSTRACT
AIM:
To determine whether alpha-tocopherol or beta-carotene supplementation affects diabetic macrovascular complications and total mortality.METHODS:
This study was carried out as part of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a double-blind, randomized trial with a 2x2 factorial design. A total of 29,133 middle-aged male smokers received either vitamin E 50 mg/day or beta-carotene 20 mg/day, or both, or placebo for a median of 6.1 years. At base-line, 1700 men had type 2 diabetes. Of these men, 662 were diagnosed with first-ever macrovascular complication, and 1142 died during the 19-year follow-up.RESULTS:
Neither supplementation affected the risk of macrovascular complication or total mortality during the intervention period. For the alpha-tocopherol-supplemented versus no alpha-tocopherol-supplemented, and beta-carotene-supplemented versus no beta-carotene-supplemented we found relative risk (RR) 0.84 (95% confidence interval (CI) 0.65-1.10) and RR 1.15 (95% CI 0.89-1.50) for macrovascular complication, respectively, and RR 1.00 (95% CI 0.80-1.25) and RR 1.06 (95% CI 0.85-1.33) for total mortality, respectively. No essential changes were found in these effects when the follow-up was extended up to 19 years.CONCLUSION:
Alpha-tocopherol or beta-carotene supplementation has no protective effect on macrovascular outcomes or total mortality of diabetic male smokers.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Vitaminas
/
Beta Caroteno
/
Alfa-Tocoferol
/
Diabetes Mellitus
/
Angiopatías Diabéticas
Tipo de estudio:
Clinical_trials
/
Etiology_studies
País/Región como asunto:
Europa
Idioma:
En
Revista:
Ann Med
Año:
2010
Tipo del documento:
Article
País de afiliación:
Finlandia