Reduction of rattlesnake-venom-induced myonecrosis in mice by hyperbaric oxygen therapy.
J Emerg Med
; 9(1-2): 1-7, 1991.
Article
en En
| MEDLINE
| ID: mdl-2045641
ABSTRACT
Hyperbaric oxygen therapy (HBOT) at 1, 2, and 2.75 atmospheres absolute (ATA) was used to treat rattlesnake (Crotalus atrox) venom-induced tissue damage and edema in thigh muscles of mice. Tissue damage was evaluated by double-blind histopathologic examination tissue edema was determined by measuring tissue water content. A total of 10 intermittent exposures to oxygen over a period of 4 days at 2 and 2.75 ATA did not influence the resolution of venom-induced tissue edema, whereas tissue damage was significantly ameliorated as compared to air-treated envenomated controls. HBOT also promoted healing in the venom-injected mice as evidenced by the presence of regenerating muscle cells. It is concluded that HBOT may limit rattlesnake venom-induced myonecrosis and promote healing in a dose-response relationship without reducing venom-induced edema.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Oxigenoterapia_hiperbrica
Asunto principal:
Venenos de Crotálidos
/
Edema
/
Oxigenoterapia Hiperbárica
/
Enfermedades Musculares
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
/
Prognostic_studies
Idioma:
En
Revista:
J Emerg Med
Año:
1991
Tipo del documento:
Article