Structure determination of two new monocillin I derivatives.
Nat Prod Commun
; 5(5): 801-4, 2010 May.
Article
en En
| MEDLINE
| ID: mdl-20521550
ABSTRACT
Biotransformation of monocillin I (1) by Beauveria bassiana ATCC 7159 was investigated. Two new derivatives 2 and 3 were isolated and identified on the basis of the spectroscopic data. Compounds 2 and 3 are synthesized by hydration at 10,11-double bond and hydrolysis of 14,15-epoxide, respectively. The R configuration of 11-OH in 2 was established by the modified 2-methoxy-2-trifluoromethylphenylacetic acid (MTPA) method. The conversion of 1 to 2 and 3 was reconstituted in an acid solution, indicating that the formation of 2 and 3 is an acid-catalyzed instead of an enzymatic process.
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Bases de datos:
MEDLINE
Asunto principal:
Compuestos Policíclicos
/
Ascomicetos
/
Productos Biológicos
/
Biotransformación
/
Beauveria
/
Lactonas
Idioma:
En
Revista:
Nat Prod Commun
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos