Two new lignans from the roots of Pulsatilla koreana.
Planta Med
; 77(1): 66-9, 2011 Jan.
Article
en En
| MEDLINE
| ID: mdl-20645248
ABSTRACT
Two new lignans, (2 R,3 R)-2 ß-(4''-hydroxy-3''-methoxybenzyl)-3 α-(4'-hydroxy-3'-methoxybenzyl)-γ-butyrolactone 2-O-( ß-D-glucopyranoside) (1) and (1 S,2 R,3 S)-dimethyl-1,2,3,4-tetrahydro-3,6,7-trihydroxy-1-(3',4'-dihydroxyphenyl)naphthalene-2,3-dicarboxylate (2) together with nine known compounds (3-11) were isolated from the ethyl acetate fraction of the roots of Pulsatilla koreana. Their chemical structures were established based on physicochemical and spectroscopic data analyses. All isolates were investigated for their inhibition effects against the classical pathway of the complement system. Among them, compound 6 showed significant inhibitory activity with an IC (50) value of 75.9 µM, compounds 8 and 9 had moderate effects with IC (50) values of 182.2 and 166.5 µM, respectively.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Lignanos
/
Pulsatilla
Idioma:
En
Revista:
Planta Med
Año:
2011
Tipo del documento:
Article