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ErbB receptor signaling in astrocytes: a mediator of neuron-glia communication in the mature central nervous system.
Sharif, Ariane; Prevot, Vincent.
Afiliación
  • Sharif A; Inserm, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the postnatal Brain, Lille, France. ariane.sharif@inserm.fr
Neurochem Int ; 57(4): 344-58, 2010 Nov.
Article en En | MEDLINE | ID: mdl-20685225
ABSTRACT
Astrocytes are now recognized as active players in the developing and mature central nervous system. Each astrocyte contacts vascular structures and thousands of synapses within discrete territories. These cells receive a myriad of inputs and generate appropriate responses to regulate the function of brain microdomains. Emerging evidence has implicated receptors of the ErbB tyrosine kinase family in the integration and processing of neuronal inputs by astrocytes ErbB receptors can be activated by a wide range of neuronal stimuli; they control critical steps of glutamate-glutamine metabolism; and they regulate the biosynthesis and release of various glial-derived neurotrophic factors, gliomediators and gliotransmitters. These key properties of astrocytic ErbB signaling in neuron-glia interactions have significance for the physiology of the mature central nervous system, as exemplified by the central control of reproduction within the hypothalamus, and are also likely to contribute to pathological situations, since both dysregulation of ErbB signaling and glial dysfunction occur in many neurological disorders.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transducción de Señal / Comunicación Celular / Sistema Nervioso Central / Neuroglía / Astrocitos / Genes erbB / Receptores ErbB / Neuronas Idioma: En Revista: Neurochem Int Año: 2010 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transducción de Señal / Comunicación Celular / Sistema Nervioso Central / Neuroglía / Astrocitos / Genes erbB / Receptores ErbB / Neuronas Idioma: En Revista: Neurochem Int Año: 2010 Tipo del documento: Article País de afiliación: Francia