Aging and antioxidants modulate rat brain levels of homocysteine and dehydroepiandrosterone sulphate (DHEA-S): implications in the pathogenesis of Alzheimer's disease.
Neurosci Lett
; 483(2): 123-6, 2010 Oct 11.
Article
en En
| MEDLINE
| ID: mdl-20691758
ABSTRACT
The study has shown that in aged (22-24 months) rat brains an elevation of homocysteine level (42%) and a decrease in dehydroepiandrosterone sulphate (DHEA-S) content (32%) occur compared to those in the brains of young rats (4-6 months). Such changes in the brain levels of homocysteine and DHEA-S in aged rats are prevented, when the diet daily of the rats is supplemented with a combination of antioxidants (N-acetyl cysteine 50 mg, alpha-lipoic acid 3 mg and alpha-tocopherol 1.5 mg - each per 100 g of body weight) starting from 18 months until these are sacrificed between 22 and 24 months. The brain content of reduced glutathione is also decreased in aged rats as compared to that in young ones and the phenomenon can again be prevented completely by the same regimen of antioxidant supplementation. The changes in the levels of homocysteine and DHEA-S in aged rat brain have been related to associated glutathione depletion and oxidative stress and the implications of the results highlighted in the pathogenesis of Alzheimer's disease.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Encéfalo
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Envejecimiento
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Sulfato de Deshidroepiandrosterona
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Enfermedad de Alzheimer
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Homocisteína
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Antioxidantes
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
Idioma:
En
Revista:
Neurosci Lett
Año:
2010
Tipo del documento:
Article
País de afiliación:
India