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Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks.
Lu, Zhaolian; Jia, Qi; Wang, Rui; Wu, Ximin; Wu, Yingchun; Huang, Caiguo; Li, Yiming.
Afiliación
  • Lu Z; Department of Biochemistry and Molecular Biology, Second Military Medicinal University, Shanghai 200433, China.
Phytomedicine ; 18(4): 298-302, 2011 Feb 15.
Article en En | MEDLINE | ID: mdl-20851586
Procyanidin oligomers in Cinnamon are thought to be responsible for the biological activity in the treatment of diabetes mellitus (DM). To clarify types of procyanidin oligomers in different Cinnamon species and investigate their different effects, the present study investigated procyanidin oligomers in polyphenolic oligomer-rich extracts of three Cinnamon samples by LC-MS methods, and their hypoglycemic activities were detected in vivo and in vitro. The results showed that two of the three samples from Cinnamomum cassia were rich in B-type procyanidin oligomers, and the other sample was rich in A-type procyanidin oligomers. The Cinnamon extracts were administered at doses of 200 and 300 mg/kg body wt. in high-fat diet-fed and low-dose streptozotocin (STZ)-induced diabetic mice for 14 days. The results showed that blood glucose concentrations were significantly decreased in all Cinnamon extract groups compared with the control group (p<0.05). Administration of the Cinnamon extracts significantly increased the consumption of extracellular glucose in insulin-resistant HepG2 cells and normal HepG2 cells compared with the control group. These results suggest that both A- and B-type procyanidin oligomers in different Cinnamon species have hypoglycemic activities and may improve insulin sensitivity in type 2 DM.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Aromoterapia / Plantas_medicinales Asunto principal: Extractos Vegetales / Cinnamomum aromaticum / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Hipoglucemiantes / Fitoterapia Idioma: En Revista: Phytomedicine Año: 2011 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Aromoterapia / Plantas_medicinales Asunto principal: Extractos Vegetales / Cinnamomum aromaticum / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Hipoglucemiantes / Fitoterapia Idioma: En Revista: Phytomedicine Año: 2011 Tipo del documento: Article País de afiliación: China