Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano).
J Nat Prod
; 73(11): 1767-74, 2010 Nov 29.
Article
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| MEDLINE
| ID: mdl-20973550
ABSTRACT
Antioxidant and antimelanogenesis activities of protocatechuic acid (1) from Origanum vulgare (oregano) were investigated. The antioxidative capacity of 1 was confirmed from its free-radical-scavenging activities, inhibition of lipid peroxidation, and suppression of reactive oxygen species in H(2)O(2)-induced BNLCL2 cells. The inhibition by 1 of tyrosinase and DOPA oxidase activity and melanin production was possibly related to the down-regulation of melanocortin-1 receptor, microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related proteins-2, and tyrosinase-related proteins-1 expression in α-melanocyte-stimulating hormone-induced B16 cells. After a gel containing 1 was applied to mice, the values of L* slightly increased, and a* and erythema-melanin levels of skin were reduced by comparing the values of untreated control groups, indicating 1 can reduce melanin production. These results suggest that 1 may act as an effective quencher of oxidative attackers with antimelanogenesis properties.
Texto completo:
1
Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Asunto principal:
Pigmentación de la Piel
/
Medicamentos Herbarios Chinos
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Depuradores de Radicales Libres
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Origanum
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Hidroxibenzoatos
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Melanocitos
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Antioxidantes
Idioma:
En
Revista:
J Nat Prod
Año:
2010
Tipo del documento:
Article
País de afiliación:
China