Omni-Stat (Chitosan) arrests bleeding in heparinised subjects in vivo: an experimental study in a model of major peripheral vascular injury.
Eur J Cardiothorac Surg
; 39(6): 952-4, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21055962
ABSTRACT
OBJECTIVE:
To explore the effectiveness of Omni-Stat (Chitosan) in a model of major haemorrhage in the presence of clotting dysfunction.METHOD:
A total of 12 major femoral artery bleeds in moderately heparinised swine treated with Omni-Stat (Chitosan) were compared with five control bleeds.RESULTS:
Haemostasis was successfully achieved at first treatment in 10 of 12 bleeds and at second treatment in the remaining two bleeds.CONCLUSION:
The study supports the evidence that Omni-Stat (Chitosan) acts independently of classical clotting pathways and should be effective in patients with clotting dysfunctions, who suffer major haemorrhage. It also suggests the potential for a role in cardiac surgery.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Hemostáticos
/
Quitosano
/
Arteria Femoral
/
Lesiones del Sistema Vascular
/
Hemorragia
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Eur J Cardiothorac Surg
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido