Fluoroquinolones in the management of community-acquired pneumonia in primary care.
Expert Rev Anti Infect Ther
; 8(11): 1259-71, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-21073291
ABSTRACT
A literature search was conducted to evaluate the pharmacokinetic and pharmacodynamic profile of the respiratory fluoroquinolones (gemifloxacin, levofloxacin and moxifloxacin) and their efficacy and safety in the management of community-acquired pneumonia (CAP). Data show that CAP is a common presentation in primary care practice, and is associated with high rates of morbidity and mortality, particularly in the elderly. Although the causative pathogens differ depending on treatment setting and patient factors, Streptococcus pneumoniae is the primary pathogen in all treatment settings. As a class, the respiratory fluoroquinolones have a very favorable pharmacokinetic and pharmacodynamic profile. Pharmacodynamic criteria suggest that moxifloxacin and gemifloxacin are more potent against S. pneumoniae, which may have the added benefit of reducing resistance selection and enhancing bacterial eradication. The respiratory fluoroquinolones are also generally well tolerated, and are first-line options for outpatient treatment of CAP in patients with comorbidities or previous antibiotic use.
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
Asunto principal:
Atención Primaria de Salud
/
Quinolinas
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Compuestos Aza
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Ofloxacino
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Infecciones Comunitarias Adquiridas
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Neumonía Bacteriana
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Fluoroquinolonas
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Levofloxacino
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Antibacterianos
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Naftiridinas
Idioma:
En
Revista:
Expert Rev Anti Infect Ther
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos